Selected Publications

2023

• Epigenetic reprogramming drives epithelial disruption in COPD. Yeung-Luk BH, Wally A, Swaby C, Jauregui S, Lee E, Zhang R, Chen D, Luk S, Upadya N, Tieng E, Wilmsen K, Sherman E, Dheeksha S, Luk M, Shrivastav AK, Cao S, Ghosh B, Christenson S, Huang Y, Ortega V, Biswal S, Tang W, Sidhaye VK. American Journal of Respiratory Cell and Molecular Biology. Accepted 19 October 2023.

• Microphysiological Models of Lung Epithelium-Alveolar Macrophage Co-Cultures to Study Chronic Lung Disease. Lagowala D, Wally A, Wilmsen K, Kim B, Yeung-Luk BH, Choi J, Swaby C, Luk M, Feller L, Ghosh B, Niederkofler A, Tieng E, Sherman E, Chen D, Upadya N, Zhang R, Kim DH, Sidhaye VK. Advanced Biology. August 15. doi: https://doi.org/10.1002/adbi.202300165.

• Cigarette smoke-induced injury induces distinct sex-specific transcriptional signatures in mice tracheal epithelial cells. Ghosh B, Chengala P, Shah S, Chen D, Karnam V, Wilmsen K, Yeung-Luk BH, Sidhaye VK. American Journal of Physiology: Lung Cellular and Molecular Physiology. August 22. doi: 10.1152/ajplung.00104.2023. PubMed PMID: 37605829.

• SARS-CoV-2 infection alters mitochondrial and cytoskeletal function in human respiratory epithelial cells mediated by expression of spike protein. Yeung-Luk BH, Narayanan GA, Ghosh B, Wally A, Lee Esther, Mokaya M, Wankhade E, Zhang R, Lee B, Park B, Resnick J, Jedlicka A, Dziedzic A, Ramanathan M, Biswal S, Pekosz A, Sidhaye VK. mBio. July 28. doi: 10.1128/mbio.00820-33. PubMed PMID: 37504520.

2022

• Loss of E-cadherin causal to pathologic changes in chronic lung disease. Ghosh B, Loube J, Thapa S, Capodanno E, Mahmud S, Girgis M, Chen S, Nishida K, Ying L, Swaby C, Wally A, Bhowmilk D, Zaykaner M, Mitzner M, Biswal S, Sidhaye VK. Communications Biology. October 29. doi: https://doi.org/10.1038/s42003-022-04150-w. PubMed PMID: 36309587.

• Epithelial plasticity in COPD results in cellular unjamming due to an increase in polymerized actin. Ghosh B; Nishida K; Chandrala L; Mahmud S; Thapa S; Swaby C; Chen S; Khosla AA; Katz J; Sidhaye V.  J Cell Science. Feb 4;. doi: 10.1242/jcs.258513. PubMed PMID: 35118497.

• Phenotypic Epithelial Changes in Laryngotracheal Stenosis. Laryngoscope. Lina IA, Tsai HW, Berges AJ, Ospino RA, Davis RJ, Motz KM, Collins S, Ghosh B, Sidhaye V, Gelbard A, Hillel AT. 2022 Feb 10;. doi: 10.1002/lary.30040. PubMed PMID: 35141889.

• The Association Between E-Cigarette Use and Prediabetes: Results From the Behavioral Risk Factor Surveillance System, 2016–2018. Zhang Z, Jiao Z, Blaha MJ, Osei A, Sidhaye V, Ramanathan M, Biswal S. ” Am J Preventive Medicine. 2022 Mar 3; https://doi.org/10.1016/j.amepre.2021.12.009. 

2021

• Long-Term Exposure to Particulate Matter Air Pollution and Chronic Rhinosinusitis in Non-Allergic Patients. Zhang Z, Kamil RJ, London NR, Lee SE, Sidhaye VK, Biswal S, Lane AP, Pinto JM, Ramanathan M Jr. ” Am J Respir Crit Care Med. 2021 Jun 28. doi: 10.1164/rccm.202102-0368LE, PubMed PMID: 34181862

2020

• Adenine Nucleotide Translocase regulates airway epithelial metabolism, surface hydration, and ciliary function.Kliment CR, Nguyen JMK, Kaltreider MJ, Lu Y, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN.J Cell Sci. 2021 Feb 1:jcs.257162. doi: 10.1242/jcs.257162. Online ahead of print.PMID: 33526710

• Why new biology must be uncovered to advance therapeutic strategies for chronic obstructive pulmonary disease.Nguyen JMK, Robinson DN, Sidhaye VK.Am J Physiol Lung Cell Mol Physiol. 2021 Jan 1;320(1):L1-L11. doi: 10.1152/ajplung.00367.2020. Epub 2020 Nov 11.PMID: 33174444 Review.

• Effect of sub-chronic exposure to cigarette smoke, electronic cigarette and waterpipe on human lung epithelial barrier function.

  Ghosh B, Reyes-Caballero H, Akgün-Ölmez SG, Nishida K, Chandrala L, Smirnova L, Biswal S, Sidhaye VK.BMC Pulm Med. 2020 Aug 12;20(1):216. doi: 10.1186/s12890-020-01255-y.PMID: 32787821

• Disruption of Sinonasal Epithelial Nrf2 Enhances Susceptibility to Rhinosinusitis in a Mouse Model.

  Ramanathan M Jr, Tharakan A, Sidhaye VK, Lane AP, Biswal S, London NR Jr.Laryngoscope. 2020 Jul 6:10.1002/lary.28884. doi: 10.1002/lary.28884. Online ahead of print.PMID: 32628788

• Strong correlation between air-liquid interface cultures and in vivo transcriptomics of nasal brush biopsy. Baishakhi Ghosh, Bongsoo Park, Debarshi Bhowmik, Kristine Nishida, Molly Lauver, Nirupama Putcha, Peisong Gao, Murugappan Ramanathan, Nadia Hansel, Shyam Biswal, Venkataramana K. Sidhaye. American Journal of Physiology: Lung Cellular & Molecular Physiology. DOI: 10.1152/ajplung.00050.2020. (May 3, 2020). [PMID: 32233789]

• Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions.

  MohanKumar K, Namachivayam K, Sivakumar N, Alves NG, Sidhaye V, Das JK, Chung Y, Breslin JW, Maheshwari A.Am J Physiol Gastrointest Liver Physiol. 2020 Apr 1;318(4):G705-G716. doi: 10.1152/ajpgi.00324.2019. Epub 2020 Feb 24.PMID: 32090604

• Jumping on the Single-Cell RNA-Sequencing Bandwagon: Take Care Not to Put the Cart before the Horse.

  Sidhaye VK, Wu M, Tesfaigzi Y.Am J Respir Cell Mol Biol. 2020 Feb;62(2):267. doi: 10.1165/rcmb.2019-0389LE.PMID: 32003599 Free PMC article. No abstract available.

• Quantifying Epithelial Plasticity as a Platform to Reverse Epithelial Injury. Kristine Nishida, Baishakhi Ghosh, Lakshmana Chandrala, Saborny Mahmud, Si Chen, Atulya Aman Khosla, Joseph Katz, Venkataramana K. Sidhaye. BioRxiv, DOI: 10.1101/2020.01.14.906008. (January 15, 2020).2020

• Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension.                                                                                 Nishida K, Brune KA, Putcha N, Mandke P, O'Neal WK, Shade D, Srivastava V, Wang M, Lam H, An SS, Drummond MB, Hansel NN, Robinson DN, Sidhaye VK.  Am J Physiol Lung Cell Mol Physiol. DOI: 10.1152/ajplung.00074.2017. (June 22, 2017). [PMID: 2864226]

2019

• Compartmentalization of anti-oxidant and anti-inflammatory gene expression in current and former smokers with COPD. Sidhaye VK, Holbrook JT, Burke A, Sudini KR, Sethi S, Criner GJ, Fahey JW, Berenson CS, Jacobs MR, Thimmulappa R, Wise RA, Biswal S.Respir Res. 2019 Aug 20;20(1):190. doi: 10.1186/s12931-019-1164-1.PMID: 31429757 Free PMC article.

• A Device for measuring the in-situ response of Human Bronchial Epithelial Cells to airborne environmental agents. Chandrala L, Afshar-Mojer N, Nishida K, Rhonzhes Y, Sidhaye V, Koehler K, Katz J. Scientific Reports, 9(1):7263. DOI: 10.1038/s41598-019-43784-5. (May 13, 2019). [PMID: 31086226]

• Nrf2 activation via Keap1 deletion or sulforaphane treatment reduces Ova-induced sinonasal inflammation. London NR Jr, Tharakan A, Mendiola M, Chen M, Dobzanski A, Sussan TE, Zaykaner M, Han AH, Lane AP, Sidhaye V, Biswal S, Ramanathan M Jr.Allergy. 2019 Sep;74(9):1780-1783. doi: 10.1111/all.13766. Epub 2019 Jun 14.

2017

• Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia. Singh SP, Chand HS, Langley RJ, Mishra N, Barrett T, Rudolph K, Tellez C, Filipczak PT, Belinsky S, Saeed AI, Sheybani A, Exil V, Agarwal H, Sidhaye VK, Sussan T, Biswal S, Sopori M.  J Immunol. 2017 May 15;198(10):3815-3822. doi: 10.4049/jimmunol.1700014. Epub 2017 Apr 5.PMID: 28381639

2016

• HIV Impairs Lung Epithelial Integrity and Enters the Epithelium to Promote Chronic Lung Inflammation                                                                                      Brune KA, Ferreira F, Mandke P, Chau E, Aggarwal NR, et al. (2016)  PLOS ONE 11(3): e0149679. doi: 10.1371/journal.pone.0149679

2015

• Pulmonary epithelial barrier function- some new players and mechanisms                                                                                                                                                        Kieran Brune, James Andrew Frank, Andreas Schwingshackl, James H.Finigan, Venkataramana K. Sidhaye. Am J Physiol Lung Cell Mol Physiol. 2015, ajplung.00309.2014; DOI:10.1152/ajplung.00309.2014

• Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function.                                                                                                  Sussan TE, Gajghate S, Chatterjee S, Mandke P, McCormick S, Sudini K, Kumar S, Breysse PN, Diette GB, Sidhaye VK, Biswal S.  Am J Physiol Lung Cell Mol Physiol. 2015; 309(1) : L27-36. DOI: 10.1152/ajplung.00398.2014. [PMID: 25957295]

2013

• Aquaporin 5 regulates cigarette smoke induced emphysema by modulating barrier and immune properties of the epithelium. Aggarwal NR, Chau E, Garibaldi BT, et al. Tissue Barriers. 2013; 1(4): e25248. DOI:10.4161/tisb.25248. [PMID: 24665410]

2012

• A novel role for aquaporin-5 in enhancing microtubule polymerization                                                                                                                                                            Sidhaye VK, Chau E, Srivastava V, Sirimalle S, Balabhadrapatruni C, Aggarwal NR, D’Alessio FR, Robinson DN, King LS.  PLoS One 2012; 7(6): e38717. DOI: 10.1371/journal.pone.0038717. [PMID: 22715407]

2011

• Septin-2 mediates airway epithelial barrier function in physiologic and pathologic conditions. Sidhaye VK, Chau E, Breysse PN, King LS. Am J Respir Cell Mol Biol. 2011; 45(1): 120-6. DOI: 10.1165/rcmb.2010-0235oc. [PMID: 20870893]

2010

• Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary disease. Hansel NN, Sidhaye V, Rafaels NM, Gao L, Gao P, Williams R, Connett JE, Beaty TH, Mathias RA, Wise RA, King LS, Barnes KC.  PLoS One. 2010; 5(12):e14226. DOI: 10.1371/journal.pone.0014226. [PMID: 21151978]

2008

• Shear stress regulates aquaporin-5 and airway epithelial barrier function. Sidhaye VK, Schweitzer KS, Caterina MJ, Shimoda L, King LS.  PNAS. 2008; 105(9):3345-50.  DOI: 10.1073/pnas.0712287105. [PMID: 18305162]